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假尿苷

CAS號(hào)	1445-07-4
規(guī)格	1KG/袋	純度	99%
貨號(hào)	ZM001	貨期	需咨詢
品牌	zhouzyme	庫(kù)存	需咨詢
規(guī)格	1KG/袋
純度	99%
貨號(hào)	ZM001
貨期	---
品牌	zhouzyme
庫(kù)存	---
注意：請(qǐng)務(wù)必與賣家聯(lián)系核實(shí)單價(jià)庫(kù)存，以確保您的資金安全及交易順利。
參考價(jià)：￥80.00 元/克

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貨號(hào)	品牌	純度	規(guī)格	參考價(jià)	貨期
ZM001	zhouzyme	99%	1KG/袋	￥80.00元/克	---

產(chǎn)品詳情

詳細(xì)信息(中文)：
mRNA疫苗是將含有編碼抗原蛋白的mRNA導(dǎo)入人體，直接進(jìn)行翻譯，形成相應(yīng)的抗原蛋白，從而誘導(dǎo)機(jī)體產(chǎn)生特異性免疫應(yīng)答，達(dá)到預(yù)防免疫的作用。
外源物質(zhì)mRNA進(jìn)入人體后，會(huì)激活人體的免疫系統(tǒng)，引發(fā)由mRNA本身引起的炎癥反應(yīng)，并可能導(dǎo)致mRNA還未發(fā)揮作用就被免疫系統(tǒng)清除。因此，引入天然修飾核苷酸是降低mRNA疫苗免疫原性的有效手段之一。
假尿苷（Pseudouridine）是RNA上最豐富的修飾核苷，又被稱為RNA的“第五種核苷”。2005年，Katalin Karikó等人發(fā)現(xiàn)將假尿苷引入RNA中能降低其免疫原性，并且RNA的免疫原性隨著假尿苷引入比例的增高而降低。2008年，Katalin Karikó等人又發(fā)現(xiàn)用假尿苷完全替代尿苷的mRNA不僅能極大地降低mRNA的免疫原性，還能提高mRNA的穩(wěn)定性并增強(qiáng)其翻譯能力。2015年，Oliwia Andries等人發(fā)現(xiàn)用N1-甲基假尿苷完全替代尿苷比用假尿苷完全替代尿苷更能降低mRNA的免疫原性，且更能增強(qiáng)mRNA的蛋白表達(dá)能力。
基于假尿苷、N1-甲基假尿苷的優(yōu)秀表現(xiàn)，和市場(chǎng)供應(yīng)受限的現(xiàn)狀，河北周酶利用自身技術(shù)優(yōu)勢(shì)，潛心研發(fā)并順利將假尿苷、N1-甲基假尿苷產(chǎn)業(yè)化，成功解決原料受限這一難題。若您對(duì)產(chǎn)品有興趣，歡迎隨時(shí)溝通。

詳細(xì)信息(英文)：
mRNA vaccines introduce mRNA encoding antigenic proteins into the body, which undergo direct translation to form corresponding antigenic proteins, thereby inducing a specific immune response in the body to achieve the effect of preventive immunity.

Upon entry of exogenous mRNA into the body, it activates the immune system, triggering inflammatory reactions caused by the mRNA itself, and may lead to clearance of the mRNA before it can exert its effect. Therefore, introducing naturally modified nucleotides is one of the effective means to reduce the immunogenicity of mRNA vaccines.

Pseudouridine is the most abundant modified nucleotide on RNA, also known as the "fifth nucleotide" of RNA. In 2005, Katalin Karikó and others discovered that introducing pseudouridine into RNA can reduce its immunogenicity, and the immunogenicity of RNA decreases with increasing proportions of pseudouridine. In 2008, Katalin Karikó and others found that using pseudouridine to completely replace uridine in mRNA not only greatly reduces the immunogenicity of mRNA but also enhances its stability and translation ability. In 2015, Oliwia Andries and others found that using N1-methyl pseudouridine to completely replace uridine can further reduce the immunogenicity of mRNA and enhance its protein expression ability compared to using pseudouridine alone.

Based on the excellent performance of pseudouridine and N1-methyl pseudouridine, as well as the limited market supply, Hebei Zhou Enzyme has utilized its own technological advantages to focus on research and development and successfully industrialized pseudouridine and N1-methyl pseudouridine, effectively solving the problem of limited raw materials. If you are interested in our products, please feel free to communicate with us at any time.

產(chǎn)品實(shí)物圖

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物理化學(xué)性質(zhì)
英文名	pseudouridine
中文名	假尿苷
CAS號(hào)	1445-07-4	溶解性	---
分子量	244.20100	熔點(diǎn)	---
密度	1.641g/cm3	沸點(diǎn)	598.4oC at 760mmHg

商家信息

河北周酶生物科技有限公司

聯(lián)系人：楊麗

號(hào)碼一： 135****

號(hào)碼二： ****

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公司類型：研發(fā)型
成立時(shí)間：2016-01-25
所在地區(qū)：河北省石家莊市
注冊(cè)資本：500萬元

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